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New Variant RVHD- Known as 'RVHD2' please ‘Watch’ thread for any updates and see new posts
- Thread starter Jack's-Jane
- Start date
So am I meant to be getting my two done? So this new one now, then the usual triple when it's due next summer? This has confused me tbh
Liz47
Wise Old Thumper
Yeah as far as I understand it from a very quick glance, you can have the new vaccine Jane linked to (if your vets can get the stock) to protect against the newer strain of rhd2 but still need the triple for myxi, rhd1 and older strain/s? of rhd2. And they can be given 2 weeks apart. That's how I read it anyway?So am I meant to be getting my two done? So this new one now, then the usual triple when it's due next summer? This has confused me tbh
joey&boo
Wise Old Thumper
Crab Lane Vets will have it in about 2 weeks. I am very relieved as the practice manager emailed me less than a week ago to say it wasn't available in UK yet & when it would be she thought it would be multi dose vials. The latter makes me nervous as I don't want my buns mixing with 50 other buns in a waiting room. Will take them in the New Year once got a chance to both take the day off work
InspectorMorse
Wise Old Thumper
SarahP
Wise Old Thumper
Vets4Pets Newmarket just shared this via Facebook
Following the initial communication about reports of a new strain please see the following statement from MSD regarding the Nobivac Myxo RHD PLUS vaccination:
'As of December 2024, we are aware of anecdotal rumors, predominantly originating from an article by Richard Saunders on the Rabbit Welfare Association website, regarding a new, highly virulent strain of rabbit haemorrhagic disease virus 2 (RHDV2). To-date, we have not seen any confirmed, scientific evidence of new, highly virulent variants of RHDV2 circulating within rabbit populations. Furthermore, there is no evidence that RHDV2 is evolving such that NOBIVAC Myxo-RHD PLUS would not provide protection against circulating strains of RHDV2, including highly virulent strains.
Nobivac Myxo-RHD PLUS has been tested against highly virulent field isolates of RHDV2 and in a peer-reviewed publication, NOBIVAC Myxo-RHD PLUS has been shown to be very effective against field strains of RHDV2, including a highly virulent isolate from Italy in 2015 (Reemers et. al 2020). Extensive searches of GenBank, NCBI, PubMed, and WOAH are all negative for evidence of a new highly virulent RHDV2 strain.
Yurvac RHD was approved by the EMA in mid-2023 and the VMD granted a marketing authorisation on 26th September 2024 (YURVAC RHD (--) - Emulsion for injection | UPD (europa.eu)). The EMA marketing authorisation was submitted in 2022 and eligibility in 2021 (ema-puar-v5992-yurvac-rhd-en.pdf).
This means that although it will have been tested against challenge from some virulent field strains of this virus it will have been in development and production for many years prior to the company launch in November 2023 (HIPRA launches YURVAC® RHD in Europe | HIPRA). Previous reports and analysis of highly virulent RHD2 strains have demonstrated that the virus still retains the same capsid protein, and therefore still appears as an RHD2 virus to the immune system.
This is important given that the Nobivac Myxo-RHD PLUS vaccine stimulates immunity against the RHD2 capsid. If the virus “looks like” an RHD2 virus to the immune system then the vaccine should continue to be protective. '
Following the initial communication about reports of a new strain please see the following statement from MSD regarding the Nobivac Myxo RHD PLUS vaccination:
'As of December 2024, we are aware of anecdotal rumors, predominantly originating from an article by Richard Saunders on the Rabbit Welfare Association website, regarding a new, highly virulent strain of rabbit haemorrhagic disease virus 2 (RHDV2). To-date, we have not seen any confirmed, scientific evidence of new, highly virulent variants of RHDV2 circulating within rabbit populations. Furthermore, there is no evidence that RHDV2 is evolving such that NOBIVAC Myxo-RHD PLUS would not provide protection against circulating strains of RHDV2, including highly virulent strains.
Nobivac Myxo-RHD PLUS has been tested against highly virulent field isolates of RHDV2 and in a peer-reviewed publication, NOBIVAC Myxo-RHD PLUS has been shown to be very effective against field strains of RHDV2, including a highly virulent isolate from Italy in 2015 (Reemers et. al 2020). Extensive searches of GenBank, NCBI, PubMed, and WOAH are all negative for evidence of a new highly virulent RHDV2 strain.
Yurvac RHD was approved by the EMA in mid-2023 and the VMD granted a marketing authorisation on 26th September 2024 (YURVAC RHD (--) - Emulsion for injection | UPD (europa.eu)). The EMA marketing authorisation was submitted in 2022 and eligibility in 2021 (ema-puar-v5992-yurvac-rhd-en.pdf).
This means that although it will have been tested against challenge from some virulent field strains of this virus it will have been in development and production for many years prior to the company launch in November 2023 (HIPRA launches YURVAC® RHD in Europe | HIPRA). Previous reports and analysis of highly virulent RHD2 strains have demonstrated that the virus still retains the same capsid protein, and therefore still appears as an RHD2 virus to the immune system.
This is important given that the Nobivac Myxo-RHD PLUS vaccine stimulates immunity against the RHD2 capsid. If the virus “looks like” an RHD2 virus to the immune system then the vaccine should continue to be protective. '
Bunny Buddy
Wise Old Thumper
Thanks for sharing that useful information (well, useful in as much as I understand it). I *think* it reiterates what Richard Saunders said (in the Q&A) ie Nobivac manufacturer's stand is that we don't need another vaccine as Yurvac won't cover anything that Nobivac doesn't already cover ...
Bunny Buddy
Wise Old Thumper
Ha, CLV told me that too but someone knowledgeable on FB said that they can order the single dose vials but that doesn't mean they will receive them anytime soon! It looks like the latter is true.
Bunny Buddy
Wise Old Thumper
That's not good to have wasted a day's leave. When I got the unsigned email (presumably from Allison), I rang to ask the cost, as that had been my original query, not the availability.. I got 'Scary' and she said she wasn't able to tell me. "It's not on the system yet. The suppliers don't tell us what to charge, we have to work out the cost." Not that I needed the attitude accompanied that - "We haven't decided" would have sufficed. She then said that they didn't have enough rabbit footfall for a 40 dose vial. I pointed out that I have 35 rabbits, to which she said, "Would you be able to bring them in one go?". Nope, but I could have done it within the 10 hours necessary, in three trips.... (I then hid). I'm too scared to ask anymore!!
PS, The road/landslide at Kex Gill might be repaired by the time the vaccine is in stock, I can't be doing with the scenic route especially in winter.
Bunny Buddy
Wise Old Thumper
Yes, exactly. I wouldn't be happy in the 48 v 2 situation either. I could have coped with me/mine using practically the whole vial ... had we been given the chance. However, if the news that Yorvac doesn't cover anything new is correct then I may have been spared spending £1k - £1.5k on something unnecessary - very much "watch this space"!
joey&boo
Wise Old Thumper
OMG. Really? Wheres this said? Tbh i've been burying my head in the sand, tryin not to think about it, but was so relieved to have a vac around the corner.
Rights thats it, Bunnies in a bubble (take on Boy in a Bubble, John travolta film I saw when I was a kid0.
Bunny Buddy
Wise Old Thumper
See SarahP's post (I might be mistranslating it, of course). Richard Saunders also referred to it on his Q&A, I discussed it with Ruth, who had also heard him say it. I'd need to be absolutely sure it does cover something different to the current vacc for the huge investment!
InspectorMorse
Wise Old Thumper
Apparently the RWAF are working on a response to this statement which challenges the claims being made. If there was still a Myxo only vaccine available I would opt for that along with Yurvac
I am not happy to accept as gospel what MSD are saying given their previous history when RVHD2 reared its ugly head. After all, MSD have a vested interest in making sure the Nobivac Myxo RHD Plus Vaccine remains the only licensed vaccination for Rabbits to cover Myxo and the strains of RHD that have been proven to be endemic in the UK.
Anyone who has a tragic loss of a vaccinated Rabbit to RHD needs to report it. This is essential in order to force the regulatory bodies to actually test for the new, more virulent strain of RHD. AFAIK this is currently not being done. The Vet who gave the vaccine should report it, but personally I would want to report it myself too.
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InspectorMorse
Wise Old Thumper
InspectorMorse
Wise Old Thumper
Highly virulent strain of RVHD2- Most recent statement from the RWAF
rabbitwelfare.co.uk
RVHD2 ‘highly virulent’ update
We are aware of a new strain of ‘highly virulent’ RVHD2 and have been working very hard to get all of the up-to-date information on this for several months. As a result, we have issued a communication to both rabbit owners and veterinary professionals to advise that all rabbits should have two...
rabbitwelfare.co.uk
Bunny Buddy
Wise Old Thumper
I am just wondering if anybody has managed to get Yurvac yet? My vets have said that they have 'fleetingly' seen the 40 dose vials available but not single dose ones.
joey&boo
Wise Old Thumper
You saved me a job. Are you going for it bb, when its accessible?
