Sammy&Patch
Warren Scout
A sad update :-(
I got the dreaded call from my vets today to say it was malignant. I think she said there was another one which was benign and also something about thickening of the uterus walls? Anyway, there is nothing we can do but wait and see if it has or does spread. She is going back to the vets beginning of January for another check up and I have to keep an eye out for change in behaviour, breathing difficulties, weight loss, not wanting to eat etc. The xray taken after her spay didn't show any spreading but the vet said it is aggressive and as it was in her lymphatics or something this means it could have spread to other lymphatic areas? (sorry if this doesn't make complete sense!) and it might not be big enough to show up yet. She mentioned something from the results about high rates of replications which I think means it is fast growing or spreading.
I thought the easiest thing would be to type out what the report said (I asked for a copy), I coudlnt' take it all in the phone call, If anyone has any knowledge of this type of cancer please let me know and please be brutally honest as I don't want to get my hope up if this really is likely to have spread:
Gross description:
Uterine masses.
a. A beige brown irregular wedge of tissue measuring 30x25x20mm. representative sections taken (3 sections)
b. A beige brown section of tubular tissue measuring 30x15x25mm with a sessile mass measuring 18x15mm. Transverse sections including inked margin taken (3 sections).
Histological description:
Uterus (6 sections). There are two distinct neoplastic processes within the uterus. Extending from the hyperplastic and expanded endometrium there is locally infiltrative, moderately well demarcated, moderately cellular, unencapsulated neoplasm variably arranged forming tubules, papillary structures, nests and cords supported by a moderately dense and proliferative stroma (desmoplasia). Neoplastic cells are large, polygonal, with indistinct cell borders, abundant eosinophilic cytoplasm that contains a single round to oval nucleus. Nuclei contain a single nucleolus and stippled chromatin. There is moderate anisokaryosis and anisocytosis, with 12 mitoses observed in ten high power fields. Neoplastic cells multifocally surround accumulations of basophilic material and rarely are identified in lymphatics. The neoplasm contains scattered low numbers of neutrophils, lymphocytes and plasma cells.
In addition the outer muscular wall is expanded by a moderately well demarcated, unencapsulated, densely cellular neoplasm arranged in short anastomosing streams and bundles, supported by a dense collagenous stroma. Neoplastic cells are moderate to large, plump spindloid, with abundant eosinophilic cytoplasm that contains a single, fusiform nucleus. Nuclei contain indistinct nucleoli and vesicular chromatin. There is mild anisocytosis and anisokaryosis, with less than 1 mitosis identified in 10 high power fields. Centrally the neoplasm small intestine replaced by necrotic debris that is focally mineralised.
Histological diagnosis:
1. Adenocarcinoma uterus
2. Leiomyoma uterus.
Comment:
The uterus contains two neoplastic masses. The endometrium is hyperplastic but there is segmental overt neoplastic transformation and infiltration, with atypia, mitoses and lymphatic invasion. These changes are consistant with progression to adenocarcinoma (rather than adenomyosis) that is accompanied by dense stromal proliferation presumed to represent desmoplasia. Given the focal lymphatic invasion, there is significant potential for metastasis and ovariohysterectomy may not prove curative in this case: periodic monitoring is recommended as a precaution.
Of lesser significance, the outer myometrium is expanded by a neoplasm of smooth muscle origin that is interpreted to represent a leiomyoma rather than leiomyosarcoma. Ovariohysterectomy is expected to prove curative for this neoplasm.
Thankyou
I got the dreaded call from my vets today to say it was malignant. I think she said there was another one which was benign and also something about thickening of the uterus walls? Anyway, there is nothing we can do but wait and see if it has or does spread. She is going back to the vets beginning of January for another check up and I have to keep an eye out for change in behaviour, breathing difficulties, weight loss, not wanting to eat etc. The xray taken after her spay didn't show any spreading but the vet said it is aggressive and as it was in her lymphatics or something this means it could have spread to other lymphatic areas? (sorry if this doesn't make complete sense!) and it might not be big enough to show up yet. She mentioned something from the results about high rates of replications which I think means it is fast growing or spreading.
I thought the easiest thing would be to type out what the report said (I asked for a copy), I coudlnt' take it all in the phone call, If anyone has any knowledge of this type of cancer please let me know and please be brutally honest as I don't want to get my hope up if this really is likely to have spread:
Gross description:
Uterine masses.
a. A beige brown irregular wedge of tissue measuring 30x25x20mm. representative sections taken (3 sections)
b. A beige brown section of tubular tissue measuring 30x15x25mm with a sessile mass measuring 18x15mm. Transverse sections including inked margin taken (3 sections).
Histological description:
Uterus (6 sections). There are two distinct neoplastic processes within the uterus. Extending from the hyperplastic and expanded endometrium there is locally infiltrative, moderately well demarcated, moderately cellular, unencapsulated neoplasm variably arranged forming tubules, papillary structures, nests and cords supported by a moderately dense and proliferative stroma (desmoplasia). Neoplastic cells are large, polygonal, with indistinct cell borders, abundant eosinophilic cytoplasm that contains a single round to oval nucleus. Nuclei contain a single nucleolus and stippled chromatin. There is moderate anisokaryosis and anisocytosis, with 12 mitoses observed in ten high power fields. Neoplastic cells multifocally surround accumulations of basophilic material and rarely are identified in lymphatics. The neoplasm contains scattered low numbers of neutrophils, lymphocytes and plasma cells.
In addition the outer muscular wall is expanded by a moderately well demarcated, unencapsulated, densely cellular neoplasm arranged in short anastomosing streams and bundles, supported by a dense collagenous stroma. Neoplastic cells are moderate to large, plump spindloid, with abundant eosinophilic cytoplasm that contains a single, fusiform nucleus. Nuclei contain indistinct nucleoli and vesicular chromatin. There is mild anisocytosis and anisokaryosis, with less than 1 mitosis identified in 10 high power fields. Centrally the neoplasm small intestine replaced by necrotic debris that is focally mineralised.
Histological diagnosis:
1. Adenocarcinoma uterus
2. Leiomyoma uterus.
Comment:
The uterus contains two neoplastic masses. The endometrium is hyperplastic but there is segmental overt neoplastic transformation and infiltration, with atypia, mitoses and lymphatic invasion. These changes are consistant with progression to adenocarcinoma (rather than adenomyosis) that is accompanied by dense stromal proliferation presumed to represent desmoplasia. Given the focal lymphatic invasion, there is significant potential for metastasis and ovariohysterectomy may not prove curative in this case: periodic monitoring is recommended as a precaution.
Of lesser significance, the outer myometrium is expanded by a neoplasm of smooth muscle origin that is interpreted to represent a leiomyoma rather than leiomyosarcoma. Ovariohysterectomy is expected to prove curative for this neoplasm.
Thankyou
