I think alot does depend on how they spent their early bunnyhood.
I've had Remus since he was quite young (we went to adopt his mother and there was only him left) and he's very affectionate and doesn't even mind being picked up that much. Both Remus and his family were handled everyday by both adults and a child, I think this made him quite bombproof. :shock:
Daphne (who's a boy) is quite affectionate as long as I'm sat down in the run with him, but doesn't like to be picked up that much, but will climb happily onto my lap for a nosie rub. He came from a possitively overcrowded place where he didn't get much attention.
Evelyn, had a bit of a questionable background, her littermate had a broken leg, neither of them were handled much and it shows, she hates being picked up and to be perfectly honest isn't that affectionate unless there is food about :roll: :lol:
Mr and Mrs Blobby, were not handled much at all in their old home and had quite a small home considering they are not exactly dwarfs, they hate being caught now however Mrs Blobby is definately getting used to it and is becoming more affectionate, similarly to Evie especially when there is food about. Mr Blobby is far more set in his way though and will often try to eat parts of me when I have to pick him up. However they are absolutely besotted with each other so I don't worry that much.
I haven't given up with any of my buns but I have to a certain extent come to accept them for what they want and like.