I think probably yes. Mine certainly seem more comfortable with their litter tray in a corner (a 'solid' corner if that makes sense, so against the hutch wall, or when they were indoors against the sofa and wall). Mine will generally face outwards rather than looking at the wall when they do their business.
I also see this preference in other areas too, not just with the litter tray. For example if I am stroking mine, they will deliberately turn around so that they are facing away from me, I suppose so that they feel they can get away quickly if they need to.