Neutered male bunny suddenly pestering neutered female badly after years of harmony!

Sammy&Patch

Warren Scout
We've had Hazel (female) for 5 years (estimated age 7-8 years), and Shadow (male) for 4 1/2 years (estimated age around 6 years). They were a difficult bond at the start but have been living in harmony for about 4 years. The are indoor bunnies, they have free roam 24/7 of 2 rooms, a large hallway, stairs, large downstairs hallway. They can also come in our bedroom off the hallway when we are in there. They have both been neutered years ago.
Shadow tends to attempt to pester Hazel by chinning her back and making weak attempts to get on her but she just has to hop away a couple of steps and he mainly gives up. Sometimes he continues a little longer and follows her but nothing bad and everything is fine between them, I've never been concerned about it. But this last week for some reason he has decided to start pestering her really badly, properly trying to get on top of her, she keeps trying to get away and he won't give up. She ends up trying to hide in a wicker tunnel thing where he can't really get to her easily, but he still tries. They both love food but when we put their veg or nuggets down he is mainly more interested in trying to pester her, or eat a bit and then pester her. She wants to eat but he keeps disturbing her so she gives up. I am now having to sit with them to keep him away from her so she can eat, usually they eat side by side without problem and I leave them to it. Both of them are still eating but I noticed her poos are smaller than usual. They have a lot of space so for example now she is downstairs and he is still upstairs so she is getting some respite. We have a pet camera so I've been keeping an eye on them when I'm elsewhere and it just seems that while he's around her he won't give up, he is actually mounting her and she's letting him a bit at times but it doesn't seem enough. The periods when he's resting/sleeping she seems happy to be next to him or nearby even though she could go off elsewhere. Yesterday I checked his anal glands as they had been blocked before and they were blocked again which was rock hard, I managed to carefully remove it. I don't know if that is relevant. Hazel is clearly upset by all this but at the moment not enough to stop her eating and running over for her food etc (yet!). So far she has been ok with him, not reacting badly other than wanting to get away but I noticed one instance yesterday when she turned round to him, put her head down. I stroked both their heads but when I stopped, he moved and she lunged at him a bit, he turned back and she lunged again but I stopped them. It didn't look like she bit him but I feel that could easily have turned into a fight which they haven't had for years. They sometimes get a little like that when you're giving them any food if you don't put it down quick enough but it's solved by putting down the food quickly, then they will eat happily together.
To note, health wise, Hazel has long term sneezes, snuffly nose, but that's not any worse than normal. Shadow seems in good health at the moment.

I don't want to seperate them if possible in case it breaks their bond so I don't know what to do. I tried pushing him off her but that seemed to make him even more determined. I tried gently pushing his head down but that didn't seem to make a difference. I picked him up off her and carried him away from her, when I put him down I stroked him a bit and he settled, she ate her veg. When I stopped he came back towards her but then just lay down at the top of the stairs (a spot she likes but he doesn't normally sit in) and he was breathing quite fast. He didn't want his veg or anything then but then he bounced back a few minutes later and ate as normal. He did similar the evening before and I thought something was wrong but I think it was just he wore himself out keep following her.

I would appreciate any ideas or advice if you've had a similar experience. I thought about a spray water bottle which is what helped when I was bonding them but that was to stop the aggression between them rather than this type of pestering. The main thing is I don't want Hazel to be more and more upset and not want to eat but I am trying to be careful to not upset Shadow either. He is spooked more easily than Hazel and when we had people staying over the summer he would run off more than normal for a week or so after and then he settled back to normal. When we've had to do ear drops before he again was more skittish and run away at the smallest noise. He's been great again lately only running off if there was a loud noise or something. So it would be a shame if me trying to stop him makes him anxious around me. Unfortunately Hazel doesn't tend to jump up on high things, which Shadow does, so she can't escape him that way.
Thankyou for any help.
 
Just to add they both groom each other usually and if they both wanted a particular piece of cabbage for example they will snatch it out of each others mouths, neither of them are afraid of the other to get what they want and it doesn't end up in a fight. So I have not felt like one of them is obviously more dominant than the other, other than Shadows usual weak attempts at mounting. They both demand grooming from each other and Hazel is not afraid to push past Shadow etc. My previous bonded bunnies were easy to see that one was dominent.
 
A sudden onset of hormonal behaviour in a neutered Buck can be a symptom of a problem with the adrenal gland- adrenal gland hyperplasia. In the first instance I would suggest a Vet consultation.


*WARNING GRAPHIC IMAGES ON LINK*


Please don’t use a ‘punishment’ (spray water at him) to correct the behaviour, he might be doing it because he’s unwell.
Thankyou, I hadn't heard of that, I will get him a vet appointment and see what they say.
 
Just an update, I took Shadow to the vet monday, she checked him over and his weight is same as normal, she felt him and couldn't feel anything. He seems fine visually etc. She is a good vet and I trust her with my bunnies but she hadn't heard of the adrenal gland hyperplasia so said she would consult with a new colleague who specialises in exotics to see what bloods or scans we might do. I got a phone call today to bring him in for bloods as the other vet thought it did sound like it could be anal or adrenal gland disease (I can't remember which she said). I saw the new vet and she asked if anything was different at home which I said there wasn't so she thought likely to be something wrong. She wanted to do bloods to test the testosterone levels. The bloods will take about a week to get results. Unfortunately she said if the testosterone is high the next steps are limited and there is not much research around, maybe due to under reporting of it. She said we could try an implant but they are not always successful. As far as any operating, that would be a referral as it would be microsurgery which they don't have the expertese for at my vets. They do operate on bunnies at my vets but not for something like this which would be very difficult. It would mean having to travel about 3-4 hours which I don't think is a good option. My vets is 5 minute walk, on monday I took him to another of their branches as that's where my usual vet was working that day, that was a 20 minute car ride and stressed Shadow out. I feel a stressful long journey just before operating would lower his chances of pulling through ok, maybe I'm wrong but that's my gut feeling. As far as scanning, they can scan at my vets but again the vet thinks it would be unlikely to show anything up on their machines so would again be a referral. Their machines are better for cat sized upwards. They can show up cysts and things in bunnies but if there was something wrong in Shadow it could be very small. So I'm keeping my fingers crossed that (assuming the testosterone is high) that the implant can help. I asked if we couldn't do anything, like if the implant didn't work, what the outlook was. She said he could have fur loss and lose weight etc but didn't think it would be fatal. I said I probably wouldn't be able to keep the bunnies together much longer if things didn't improve which would be a shame for both of them, I think they would both be depressed splitting up and they would end up with a lot less space than they are used to as well. I really really hope things get better for the both of them!!!
 
I have had 3 Rabbits who developed adrenal gland hyperplasia, all responded well to the Suprelorin implant.

I did have to separate them from their bonded partners until they were on treatment as it was far too stressful for them to remain together with their respective partners until the AGH symptoms were under control. Fortunately I was able to rebond them all.



Edited to add, an Exotics Vet gave me the following links to read. Some require subscribing to the site, your Vet might already do so and it’d be good for her to see the articles. For general interest if nothing else. For example it is suggested that AGH is a very rare consequence of neutering.

*WARNING* graphic images on link






As for the prognosis of unmanaged/untreated AGH. Whilst most AG tumours are benign, there are types that can be malignant (cancerous) and metastasise. This happened with one of my affected Bucks. Disease spread to his lungs, which is actually very unusual. The organs a malignant AG tumour can metastasise to are usually the kidneys, the liver and the pancreas.

Prognosis is also based on quality of life if the condition cannot be surgically or pharmacologically managed. That is something that needs to be judged on an individual case basis.
 
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I have had 3 Rabbits who developed adrenal gland hyperplasia, all responded well to the Suprelorin implant.

I did have to separate them from their bonded partners until they were on treatment as it was far too stressful for them to remain together with their respective partners until the AGH symptoms were under control. Fortunately I was able to rebond them all.



Edited to add, an Exotics Vet gave me the following links to read. Some require subscribing to the site, your Vet might already do so and it’d be good for her to see the articles. For general interest if nothing else. For example it is suggested that AGH is a very rare consequence of neutering.

*WARNING* graphic images on link






As for the prognosis of unmanaged/untreated AGH. Whilst most AG tumours are benign, there are types that can be malignant (cancerous) and metastasise. This happened with one of my affected Bucks. Disease spread to his lungs, which is actually very unusual. The organs a malignant AG tumour can metastasise to are usually the kidneys, the liver and the pancreas.

Prognosis is also based on quality of life if the condition cannot be surgically or pharmacologically managed. That is something that needs to be judged on an individual case basis.
Thankyou for all the info and advice. I'm hoping the blood results will be back tomorrow or friday. Shadow has calmed down quite a lot the last couple of days even though nothing else has changed. He still pesters her here and there but no where near as relentless. He seems to be following her a lot and doing half hearted attempts then giving up. I don't know if he has worn himself out! They haven't had any fights that I know of and are still happily sitting/lying together a lot, he seems to be demanding a lot of grooming from Hazel which she is doing. Do you know if a bunny can have the disease but the symptoms fluctuate, like he could calm down for a bit and then flare up again but still have the underlying problem? If the bloods come back with the high testosterone but he has calmed down, would you still do the implant or wait and see if the pestering was bad again? My vet will advise me on that I'm sure but I thought it would be good to get thoughts on here too. Thankyou
 
Thankyou for all the info and advice. I'm hoping the blood results will be back tomorrow or friday. Shadow has calmed down quite a lot the last couple of days even though nothing else has changed. He still pesters her here and there but no where near as relentless. He seems to be following her a lot and doing half hearted attempts then giving up. I don't know if he has worn himself out! They haven't had any fights that I know of and are still happily sitting/lying together a lot, he seems to be demanding a lot of grooming from Hazel which she is doing. Do you know if a bunny can have the disease but the symptoms fluctuate, like he could calm down for a bit and then flare up again but still have the underlying problem? If the bloods come back with the high testosterone but he has calmed down, would you still do the implant or wait and see if the pestering was bad again? My vet will advise me on that I'm sure but I thought it would be good to get thoughts on here too. Thankyou
The severity of the symptoms can fluctuate a lot. Just because they have subsided at the moment it doesn’t mean the problem has gone away. If the bloods show high testosterone personally I would want to proceed with the implant. But you need to be guided by your Vet. 😀
 
Thankyou, that was my gut feeling I doubt it has gone away for good and still underlying issue. I also think I would probably still do the implant but will discuss with my vet. Thanks for your opinion on it :)
 
The severity of the symptoms can fluctuate a lot. Just because they have subsided at the moment it doesn’t mean the problem has gone away. If the bloods show high testosterone personally I would want to proceed with the implant. But you need to be guided by your Vet. 😀
Hi again, I phoned the vets today, they have the results which were very low testosterone, just like a bunny who has been neutered. The vet I saw is off ill so I will have to wait to speak to her about other suggestions or what to do next. Do you know if they can still have the issue but not show high testosterone? I am so confused, I was expecting the answer to be easy, high testosterone and we would do the implant!
 
Hi again, I phoned the vets today, they have the results which were very low testosterone, just like a bunny who has been neutered. The vet I saw is off ill so I will have to wait to speak to her about other suggestions or what to do next. Do you know if they can still have the issue but not show high testosterone? I am so confused, I was expecting the answer to be easy, high testosterone and we would do the implant!
It’s not something I have encountered, but I would suggest a repeat test in 3 months time. Unless the symptoms fully resolve and do not recur.
 
It’s not something I have encountered, but I would suggest a repeat test in 3 months time. Unless the symptoms fully resolve and do not recur.
Hi, just thought I would give a quick update, Shadow hasn't done any more pestering lately but he had been doing his head twitching/tic a bit more than normal (another thread a couple years back you advised me on that). I asked if we could xray him to check there wasn't a middle ear infection and also asked if it was worth xraying his whole body at the same time so they did that last tuesday. They didn't find anything in the ears (although I do understand an xray might not pick it up) but it did find he has fluid on the lungs and a rounded heart :-( The vet mentioned something about there can be dementia like symptoms with heart issues which can cause behaviour changes which could have been why he was behaving out of character, and could also cause the twitch/tic, she said it looked like an involuntary muscle movement. She also said it could have been caused by his previous ear infections causing some damage, I don't think we will ever know. She's given him loxicom which she wants to see if it makes any difference to his head twitches, a diuretic and a heart pill. I have to take him back a week on monday and I'm assuming she will decide which medicine to continue (I think the pill he will just take forever). I'm so glad we did the xrays, although I don't want him to have a heart problem, at least we can do something about it and I thought something was definitely wrong. Fingers crossed the medicine will help and he can live as good a life as possible, he seems pretty happy right now so that's good!
 
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