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Floppy Rabbit syndrom

BunnySeasons

New Kit
Hi everyone,

This is the first time I post here, but I have been a lurker for years now to find any information I could when I needed it. It's always been very helpful.

Unfortunately I'm facing a tough situation with my little Yuki (snow in Japanese). She is a minilop, turning 5 this year.

On the 25th of Feb, I took her to the vet because she had stopped eating and was showing signs of pain. I figured it was GI stasis but it turned out that she had dental spurs, and to make matters worse, they had hurt her tongue and cheek. So we scheduled the procedure for the following morning, but that same evening, things got worse and she was in too much pain (I won't go into details about how she expressed it because I'm still suffering trauma from seeing it) that I took her to out of hours vet where they gave her an opioid (Buprenorphine) which of course knocked her out all night long. I pretty much spent all night awake with her in my bed to make sure she wouldn't stop breathing.

Come the morning, took her to the vet and left her to get the procedure done. At 4:30pm I got the call that everything went well and that I could pick her up. She was still a bit out of it, subdued. They clarified that they sedated her and didn't use any anaesthetic.

As expected, she wasn't eating for the first few days on her own because of the sores in her mouth. Tyring to give her Critical care/Recovery food has always been pretty much useless with Yuki because she ends up spitting it out cheeky little thing. She would have some mashed pellets though but not enough to nourish her enough clearly. Bananas were still very much accepted at least so she was obviously looking for soft foods.

By the 3rd of March there wasn't any improvement so I got even more worried. She also had clearly lost some weight as I could feel her little spin more than ever. And yes, she had lost a little less than 100 grams during that week poor thing. Vet prescribed more Meloxicam and Metoclop which she had been on since the dental procedure, changing the dose a little for the Meloxicam.

Back at home, I kept trying to feed her everything I knew she liked. A bunch of fresh grass from the garden, hay, pellets, etc.

And then things changed... for the worse. Her hind legs started to appear weaker and weaker. She was still hopping around when needed but I could see it was a bit off. She would prefer to remain hidden under the footstool she uses to sleep with her boo, Haru, and she would eat just bits and pieces. The sores by this point had healed so it didn't make sense for her to not eat. She was also passing droppings (at least that's something) which was a big change from the week before.

Over the weekend things, again, got a bit worse and I had to wait until Monday to go to the vet. By this point, her hind legs were MUCH weaker and the vet said that there might be some pain because Yuki flinched twice while checking her legs and hips. So another round of Buprenorphine which I wasn't too keen on because it meant at least 12 hours without eating again because she was too out of it and I was starting to feel like it might be FRS. The vet sent me home with a course of Panacur in case it's EC. I asked about Vit E but she pretty much dismissed me.

Here's the thing. I'm currently going through health issues myself, unemployed and on benefits so I had to go to a PDSA hospital to get her treated rather than my usual vet so obviously they can't do all the tests on her. But her symptoms seemed to be either EC, activated by the stress of the procedure, pain, (especially the night before the treatment; or FRS because she has the typical frog legs, she still tried to get away from me when she is annoyed by me hovering. There is no head tilt, no disorientation, she knows exactly where she is and what is what. So I'm more inclined on it being FRS which would also make sense considering the lack of nutrition she went through during the first week. I tried, really tried to make her eat things, but like I said, recovery/Critical care food would just end up on the floor despite me me giving it to her in tiny bits through a syringe. I feel guilty about it, because I think had I insisted and forced her she wouldn't be where she is but on the other hand I could have caused her a heart attack with all the handling.

It's now the 12th. She has been on Panacur since the 9th and I started her on Vit E myself yesterday afternoon, so she had two doses already. But nothing in her strength has changed. I would like to think that it's too soon to see any changes. She eats bits and pieces (today was a bit less than yesterday), She only ended up having some herbs about 4 hours after I put them in front of her. Banana is always welcome (cheeky thing), pellets were okay-ish about 2 hours ago. Critical care is still a no-no, still ends up everywhere except her mouth. Absolutely no hay, but some grass from the garden at least.

She does try to move when she wants to which gives me hope, but I feel so sorry for her because it's so exhausting for her that she ends up needing to rest for a long time after just trying to move for 5 seconds.

Sorry for the long post, but I wanted to explain the whole story.

Anybody who had a bunny with FRS that made a recovery some time after starting to administer Vit E by any chance? Anybody who needed to make the tough decision that I don't even want to think about because I'll just cry more than I already am?

Yuki was never one to be cuddled too much, she liked her space. But for the first time now, every time I help her stay a bit upright to give her some relief she ends up licking my hands and it both melts and breaks my heart. She never licked me and I think she uses my hand to kind of groom herself because she can't do it with her own front paws. She ends up rubbing her face gently against my hands after a few licks, bless her.

For what it's worth, unless she tumbled over somewhere while I was sleeping, she didn't break her spine or anything. They spend the night with me in my attic bedroom, large enough for them to still do zoomies if they wanted to, so I didn't hear anything.
 
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I'm sorry you have a poorly rabbit. She really needs a full examination and further tests at a vet, but here are my thoughts:

Floppy Rabbit Syndrome is described here:

I've had a rabbit with FRS once. He was totally limp, like during a general anaesthetic. A higher potassium diet (ie bananas) brought him round within a short time (ie a couple of days or so? I can't remember the details - it was decades ago). The article says that the liver is affected.

EC can cause hind leg weakness and is common in rabbits, particularly at times of stress. Treatment is daily oral Panacur and an anti-inflammatory (eg matacam) for cycles of 28 days. The parasite is shed via spores in the urine. Kidneys are often affected.

Hind leg problems may also be due to injury (spinal, hips, etc) or infection.

Ideally, I would be asking for x-rays and a full blood profile along with a full physical examination to determine what's wrong. Often there's a broad approach to treatment if no obvious cause is found - eg metacam (pain relief and anti-inflammatory), antibiotic in case of infection, and Panacur for EC. Metacam and antibiotics are pescription-only meds, but it may be cheaper to pay your vet for a prescription and get the meds from an online supplier (there are several reputable ones). Panacur is available without a prescription. I use the 10% liquid for cats & dogs as it's cheaper for longer courses / multiple rabbits, and much more accurate to dose than the syringes of paste marketed for rabbits.

Rabbits need to eat continually to keep their guts working. If she's eating grass, I would keep feeding her as much of that as she will eat as it's the best thing for her digestion. If she isn't eating normally, she will probably also need meds to keep her guts moving until she is eating and pooing normally.
 
I'm sorry you have a poorly rabbit. She really needs a full examination and further tests at a vet, but here are my thoughts:

Floppy Rabbit Syndrome is described here:

I've had a rabbit with FRS once. He was totally limp, like during a general anaesthetic. A higher potassium diet (ie bananas) brought him round within a short time (ie a couple of days or so? I can't remember the details - it was decades ago). The article says that the liver is affected.

EC can cause hind leg weakness and is common in rabbits, particularly at times of stress. Treatment is daily oral Panacur and an anti-inflammatory (eg matacam) for cycles of 28 days. The parasite is shed via spores in the urine. Kidneys are often affected.

Hind leg problems may also be due to injury (spinal, hips, etc) or infection.

Ideally, I would be asking for x-rays and a full blood profile along with a full physical examination to determine what's wrong. Often there's a broad approach to treatment if no obvious cause is found - eg metacam (pain relief and anti-inflammatory), antibiotic in case of infection, and Panacur for EC. Metacam and antibiotics are pescription-only meds, but it may be cheaper to pay your vet for a prescription and get the meds from an online supplier (there are several reputable ones). Panacur is available without a prescription. I use the 10% liquid for cats & dogs as it's cheaper for longer courses / multiple rabbits, and much more accurate to dose than the syringes of paste marketed for rabbits.

Rabbits need to eat continually to keep their guts working. If she's eating grass, I would keep feeding her as much of that as she will eat as it's the best thing for her digestion. If she isn't eating normally, she will probably also need meds to keep her guts moving until she is eating and pooing normally.

Thanks for the info.

That syringe of Panacur they gave me is horrible to be honest. I completely messed up the first few dosages. If I don't see any improvement once I'm out I'll see if I can get the one you mention just to complete the full 28 days.

I'm not sure whether kidneys are affected because she does drink water when I help her with a syringe. Nothing crazy, just normal. She just needs help because all four limbs are affected and holding her up to drink from the bowl is a recipe for a fight. As poorly as she is, she still wants to kick me in the face when I need to handle her.:sneaky: And the colour of her urine looks healthy as well, she does pee normally, without even soiling herself.I can see her fluffy pompom lifting while she is laying down which tells me that she has peed in her frog like position.

I think it's really just a matter of being patient at this point. She hasn't gotten any worse, nor any better. She still eats, she tries to get out of my claws when I handle her and she makes it known when she wants to move somewhere else, especially closer to her partner. Poor Haru doesn't know what's going on and kind of misses her. Every time he tries to cuddle up to her, her legs get in the way.
 
Hi Bunny Seasons,

I just replied on my thread but saw this post. Just wanted to add, as I can see you said you struggle with critical care…

There is an apple and banana flavoured critical care if you haven’t tried this one yet. Both my bunnies turned their nose up at the other one but were both banana fanatics and were eventually won over.

I did have to leave some on a plate for one of them and he eventually started having a bit and soon after he really looked forward to it. With Bella, she wasn’t sure at first and I gave her it on a teaspoon. She also learned to love it!

Definitely worth trying the alternative flavour if you haven’t already.

Sorry to hear that you are going through a difficult time yourself too.
 
Hi Bunny Seasons,

I just replied on my thread but saw this post. Just wanted to add, as I can see you said you struggle with critical care…

There is an apple and banana flavoured critical care if you haven’t tried this one yet. Both my bunnies turned their nose up at the other one but were both banana fanatics and were eventually won over.

I did have to leave some on a plate for one of them and he eventually started having a bit and soon after he really looked forward to it. With Bella, she wasn’t sure at first and I gave her it on a teaspoon. She also learned to love it!

Definitely worth trying the alternative flavour if you haven’t already.

Sorry to hear that you are going through a difficult time yourself too.

Hi again!

That's the one I have but she hates it. I think I traumatised her by trying to give it to her with a syringe the first time. I will see if by putting it on a small plate from now on makes a difference.
 
Worth a try! Could sprinkle some of her pellets on it. If not, you could always try the other flavour as one of my rabbits preferred this one but wouldn’t have the banana one. I know it’s expensive though, I know you mentioned you were on benefits. These rabbits are fussy little beggars. Don’t give up with the critical care. Just maybe leave it in small amounts until she takes to it. Fingers crossed. X
 
I have no experience with FRS, yet plenty giving critical care. Start by adding more or less water to the mix of critical care. Since she likes banana try adding a little critical care powder to mashed banana. Start with a small amount and.slowly increase the amount of critical care if she takes it.
Also, wet her regular pellets.
Sending lots of positive vibes that she can recover.
 
I wanted to let everyone know, that last night I had to let go of my little angel, Yuki. I managed to get tests done on her, including x-rays and it showed that the roots of her molars had grown abnormally, too severe to make a difference even with frequent dental procedures and care at home. She had gone into sepsis.

The vet did not relate it to her diet, but rather a horrible genetic consequence of lop breeding. We decided that the best course of action would be to let her rest instead of having to face a life full of uncertainty and most likely constant discomfort even though pain management would be involved.

She fell asleep in my arms, so light, so fragile. My grief is immense right now and I don't know how long I will need to start feeling better.

I will miss my little firecracker. She has been one of the brightest two lights in my life, alongside Haru who is feeling her absence as well right now. I need to be strong for him, give him all the love he deserves and more.

Rest in peace, princess. You were going to turn 5 this year. You will be forever loved. Go chase your pieces of endless smooth banana and run around in lush green grass fields on the other side of the rainbow bridge.

If you have a lop, make sure your vet does a CT scan during every check up as well. I had 4 in my entire life for them, and none of them, despite claiming to be rabbit-savvy, ever mentioned a CT scan being beneficial to check for the condition of her teeth underneath her gum. Dental issues can be invisible and they creep up on you unexpectedly.

The human race is evil for forcing such genes on an innocent creature

Yuki.jpg
 
Oh beautiful Yuki ☹️, she is an angel. What a gorgeous girl. You must be devastated.

I am so sorry to hear this. No one can deny that you gave her so much love and care, and she will have felt that all the way. I’m sorry for your other little bunny too. It’s awful. It will get better in a few days and you will be able to function (and at least not be fully paralysed by grief). But we miss our babies forever.

I totally agree regarding Lops. I will only adopt rescue rabbits and will never buy from a breeder or pet shop as we need to try and end the cycle. Of course most rabbits in animal rescue will have originated from the same places but at least we are removing the profitability of cruel breeding practices while also giving a bunny a loving and experienced home (and not a hutch/cage).

Loki (the black and white lop in my picture) died from congenital issues with his mouth and throat too. He was only 5. It seems to be about the time when these problems start to express themselves ☹️.
 
There is a piece of towel that I had placed underneath Yuki last night to absorb any pee she might release while being immobile and Haru just found it. There are still some small droppings on it as well. He misses her clearly senses her smell on it. I wanted to start tidying up their area a bit but I think that will make his grieving process worse. Last night when we got home after saying goodbye he didn't sit still for more than 30 seconds at a time, looking distressed poor thing.
 
They say to leave their body in there for a short period if they pass at home, so I think leaving the towel in there might help him. Poor Haru. Rabbits are such sensitive little souls. I have had other animals in the past but nothing hurts as much as losing a bunny. I’m glad she’s not suffering now. You did the right thing for her and have taken her pain onto yourself. She will be grateful for that.
 
I am sorry you had to let Yuki go to the rainbow bridge. She is georgeous.
I got my first lop in August and appreciate the warning.
The price of having a special bunny is the immense grief you have when you need to say goodbye.
Sending you lots of comforting hugs and head rubs for Haru.
 
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