InspectorMorse
Wise Old Thumper
HISTOPATHOLOGY
Clinical History: mass in abdomen.
Macroscopic Description:
2 beige brown irregular pieces of tissue measuring up to 30x20x10mm.
Representative sections taken (2x sections).
Microscopic Description:
Submitted samples, mass in abdomen (2 sections). The sections comprise portions
of a mass, which lacks natural borders. The mass exhibits a fibrovascular
stroma, which is infiltrated by aggregates of round cells. The majority of
these exhibits scant eosinophilic cytoplasm with indistinct cell borders. The
nuclei are oval with clumped chromatin and 1 nucleolus. There is moderate
anisocytosis and anisokaryosis. 56 mitoses are observed within 2.37 mm2
(equivalent to 10 high power fields). There are multiple large areas of
necrosis with central accumulations of mineralised material. There are
scattered macrophages, often exhibiting abundant eosinophilic cytoplasm and
containing accumulations of karyorrhectic debris or erythrocytes.
The lesion extends to the tissue borders (incisional biopsies).
Histological Diagnosis:
Round cell tumour, consistent with lymphoma, with necrosis, submitted samples,
mass in abdomen.
Comment:
The biopsies from a mass within the abdomen reveal an infiltrate of round cells
with elevated mitotic activity. The histological features are consistent with a
round cell neoplasm. Based on the cellular features, I favour lymphoma.
However, the origin of this tumour is not certain, as adjacent tissue has not
been captured. It is possible that this mass is present within a mesenteric
lymph node if this is compatible with the clinical findings. Unfortunately we
are not able to offer immunohistochemistry analysis on rabbit tissues in our
laboratory and therefore cannot offer further analysis to determine the
immunophenotype of the neoplastic cells. The tumour is expected to continue to
grow in an infiltrative manner and there is potential for metastasis from this
site.
Kerstin Erles DrMedVet FRCPath DipACVP MRCVS
Veterinary Pathology Group(VPG)
Clinical History: mass in abdomen.
Macroscopic Description:
2 beige brown irregular pieces of tissue measuring up to 30x20x10mm.
Representative sections taken (2x sections).
Microscopic Description:
Submitted samples, mass in abdomen (2 sections). The sections comprise portions
of a mass, which lacks natural borders. The mass exhibits a fibrovascular
stroma, which is infiltrated by aggregates of round cells. The majority of
these exhibits scant eosinophilic cytoplasm with indistinct cell borders. The
nuclei are oval with clumped chromatin and 1 nucleolus. There is moderate
anisocytosis and anisokaryosis. 56 mitoses are observed within 2.37 mm2
(equivalent to 10 high power fields). There are multiple large areas of
necrosis with central accumulations of mineralised material. There are
scattered macrophages, often exhibiting abundant eosinophilic cytoplasm and
containing accumulations of karyorrhectic debris or erythrocytes.
The lesion extends to the tissue borders (incisional biopsies).
Histological Diagnosis:
Round cell tumour, consistent with lymphoma, with necrosis, submitted samples,
mass in abdomen.
Comment:
The biopsies from a mass within the abdomen reveal an infiltrate of round cells
with elevated mitotic activity. The histological features are consistent with a
round cell neoplasm. Based on the cellular features, I favour lymphoma.
However, the origin of this tumour is not certain, as adjacent tissue has not
been captured. It is possible that this mass is present within a mesenteric
lymph node if this is compatible with the clinical findings. Unfortunately we
are not able to offer immunohistochemistry analysis on rabbit tissues in our
laboratory and therefore cannot offer further analysis to determine the
immunophenotype of the neoplastic cells. The tumour is expected to continue to
grow in an infiltrative manner and there is potential for metastasis from this
site.
Kerstin Erles DrMedVet FRCPath DipACVP MRCVS
Veterinary Pathology Group(VPG)
