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Nancy has EC UPDATE #29 :)

Den

Mama Doe
Following on from my recent posts in Rabbit Chat asking for vibes.

Nancy has been weeing outside of her litter tray for a while now, and has also been drinking more.

She was first at the vet in January where a urine sample was obtained and sent to the lab for analysis. She was found to have a UTI and also crystals were found to be present. A two week Baytril course was prescribed and this cleared the infection and the urinary incontinence improved considerably.

She was taken back to the vets last Monday as the urinary incontinence had returned. A further sample was obtained for analysis but returned free from infection but crystals still present. A further sample was obtained to test fof EC and my Vet called me today to confirm a positive result.

I collected Panacur (28 days)and Baytril (10 days)after work and we have a follow up appointment to see how she is next Thursday (22nd).

Nancy had been prescribed Metacam last week following an episode of pain and a slight dragging of one of her hind legs I asked my Vet if I should continue with the Metacam because of inflammation but he has said to stop the Metacam because of potential further kidney damage now that we gave this diagnosis and because she had shown no signs of improvement since she has been taking it.

I would be really grateful if anyone who has had a rabbit with EC would be able to give any advice, tips, or just share their experiences with me - in particular those who have 'only' had this symptom. When I think of EC I think head tilt and rolling. Yet apart from the urinary incontinence and excessive thirst there appears to be nothing wrong - no loss of appetite and no other signs of illness.

I am a little perplexed as to how her blood test showed that kidney function was normal when I have read that the excessive thirst and urinary incontinence is a sign of kidney failure.

And on the assumption the Panacur does the trick and kills off the parasite, is she likely to remain incontinent as I gather organ damage will remain?If so, should I consider rearguard (or similar) once it gets warmer and the flies are back?

My Vet is calling me on Thursday about Will as I think he needs to be treated too. Would he need the 28 day course too?

And finally- the cleaning/disinfecting. Nancy has wee'd everywhere. What is best to use? Vet suggested Anigene - if I use this how long before my Rabbits can go back in? I seem to recall having to do a deep clean at day 21 of treatment?? ( I will deep clean every day anyway). Should I invest in a steam cleaner and get new litter trays?

Thanks for reading.
 
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Following on from my recent posts in Rabbit Chat asking for vibes.

Nancy has been weeing outside of her litter tray for a while now, and has also been drinking more.

She was first at the vet in January where a urine sample was obtained and sent to the lab for analysis. She was found to have a UTI and also crystals were found to be present. A two week Baytril course was prescribed and this cleared the infection and the urinary incontinence improved considerably.

She was taken back to the vets last Monday as the urinary incontinence had returned. A further sample was obtained for analysis but returned free from infection but crystals still present. A further sample was obtained to test fof EC and my Vet called me today to confirm a positive result.

I collected Panacur (28 days)and Baytril (10 days)after work and we have a follow up appointment to see how she is next Thursday (22nd).

Nancy had been prescribed Metacam last week following an episode of pain and a slight dragging of one of her hind legs I asked my Vet if I should continue with the Metacam because of inflammation but he has said to stop the Metacam because of potential further kidney damage now that we gave this diagnosis and because she had shown no signs of improvement since she has been taking it.

I would be really grateful if anyone who has had a rabbit with EC would be able to give any advice, tips, or just share their experiences with me - in particular those who have 'only' had this symptom. When I think of EC I think head tilt and rolling. Yet apart from the urinary incontinence and excessive thirst there appears to be nothing wrong - no loss of appetite and no other signs of illness.

I am a little perplexed as to how her blood test showed that kidney function was normal when I have read that the excessive thirst and urinary incontinence is a sign of kidney failure.

And on the assumption the Panacur does the trick and kills off the parasite, is she likely to remain incontinent as I gather organ damage will remain?If so, should I consider rearguard (or similar) once it gets warmer and the flies are back?

My Vet is calling me on Thursday about Will as I think he needs to be treated too. Would he need the 28 day course too?

And finally- the cleaning/disinfecting. Nancy has wee'd everywhere. What is best to use? Vet suggested Anigene - if I use this how long before my Rabbits can go back in? I seem to recall having to do a deep clean at day 21 of treatment?? ( I will deep clean every day anyway). Should I invest in a steam cleaner and get new litter trays?

Thanks for reading.


Hi Den

As I mentioned on your other thread, I'm sorry to hear this, but I hope between you and the vet you can manage Nancy's condition :)

The info I have found helpful is this:


https://rabbitwelfare.co.uk/rabbit-health/e-cuniculi/

https://www.kingswoodvets.co.uk/information/rabbits

http://www.dechra.co.uk/therapy-are...cs-antifungals/disease-information/e-cuniculi


With regards to Metacam, it's use in E.C. is to control the inflammatory response as the E.C. spores erupt into organ tissue, as this can cause longer term damage. It can also make the clinical symptoms of the condition worse. But all of this needs to be weighed up against the possible side effects of the NSAID, which can include compromising the kidneys.

Will needs to be given the 28 day course of Panacur at the same time as Nancy, because otherwise she will be re-infected with spores he deposits in the litter tray (shed and spread through urine).

You are right about the cleaning - best done on days 21 and 28 of Panacur treatment to interrupt the life cycle of the parasite. I would agree with the vet's suggestion of Anigene. You can also use a 1% solution of bleach, which is sometimes good for litter trays - rinse well.

The thinking is that when an organ has been damaged by E.C. that organ will remain damaged. I haven't always found this to be the case though, and with careful nursing and vet treatment some rabbits can recover to some extent or another. There's still so much that's unknown about E.C.


I've found this article to be a mine of info on E.C.

http://www.vetfolio.com/parasitology/encephalitozoon-cuniculi-infection-in-rabbits


I'm sure you will get loads of support and info to help you and Nancy, but I hope that something here might help a little to begin with.

Good luck xx
 
Hi Den

As I mentioned on your other thread, I'm sorry to hear this, but I hope between you and the vet you can manage Nancy's condition :)

The info I have found helpful is this:


https://rabbitwelfare.co.uk/rabbit-health/e-cuniculi/

https://www.kingswoodvets.co.uk/information/rabbits

http://www.dechra.co.uk/therapy-are...cs-antifungals/disease-information/e-cuniculi


With regards to Metacam, it's use in E.C. is to control the inflammatory response as the E.C. spores erupt into organ tissue, as this can cause longer term damage. It can also make the clinical symptoms of the condition worse. But all of this needs to be weighed up against the possible side effects of the NSAID, which can include compromising the kidneys.

Will needs to be given the 28 day course of Panacur at the same time as Nancy, because otherwise she will be re-infected with spores he deposits in the litter tray (shed and spread through urine).

You are right about the cleaning - best done on days 21 and 28 of Panacur treatment to interrupt the life cycle of the parasite. I would agree with the vet's suggestion of Anigene. You can also use a 1% solution of bleach, which is sometimes good for litter trays - rinse well.

The thinking is that when an organ has been damaged by E.C. that organ will remain damaged. I haven't always found this to be the case though, and with careful nursing and vet treatment some rabbits can recover to some extent or another. There's still so much that's unknown about E.C.


I've found this article to be a mine of info on E.C.

http://www.vetfolio.com/parasitology/encephalitozoon-cuniculi-infection-in-rabbits


I'm sure you will get loads of support and info to help you and Nancy, but I hope that something here might help a little to begin with.

Good luck xx
Thank you MM- much appreciated. Especially at this hour!.

Should I assume Will is infected too then?

I use hay and newspaper in their litter trays. They are changed daily but they totally ignore the hay rack and eat the hay in the litter tray. I'm guessing this is not good given the EC?

Sent from my SM-G935F using Tapatalk
 
Thank you MM- much appreciated. Especially at this hour!.

Should I assume Will is infected too then?

I use hay and newspaper in their litter trays. They are changed daily but they totally ignore the hay rack and eat the hay in the litter tray. I'm guessing this is not good given the EC?

Sent from my SM-G935F using Tapatalk


You're welcome. I know how despondent these things can make us.

Yes, assume Will to be a carrier, as so many rabbits harbour E.C. without ever showing any symptoms throughout their lives. It would be very unlikely indeed if Nancy were positive and he were not too.

Regards the hay, it's difficult to prevent them eating what they want wherever it is, but the Panacur will decrease the E.C. spores in the urine and as long as you keep on top of the litter tray with the bleach or Anigene then you are doing the most you can to eradicate it. They will shed spores, but not forever. But E.C. spores are remarkably hardy so the cleaning has to be rigorous (which I know you will do!)

https://www.petcha.com/signs-and-diagnosis-of-e-cuniculi-in-rabbits/

Also, interesting to note ...

... if you have an infected rabbit who lives with other rabbits, is that most certainly by the time you see the outward signs of clinical disease, it is well past any contagious stage. The parasites are no longer in the kidneys. However, the spores that have been shed in the urine can remain in the environment for another month. Other rabbits can pick up spores from the environment for several weeks after the infected rabbit has stopped shedding. And since many other animal species can carry and shed these parasites, a rabbit who runs on the ground outdoors is more likely to pick them up.
 
I know we're only on day 4 of treatment but Nancy's urinary incontinence is worse. Whereas previously I was convinced she just wasn't getting to the litter tray in time this clearly isn't the case.

When I gave breakfast as she stretched and got up from her bed a shower if urine shot out from her and missed poor Will by inches.

When I scooped her up to give her meds earlier it poured out of her.:cry:

On the plus side she's eating well, as usual, and output is normal.
 
I know we're only on day 4 of treatment but Nancy's urinary incontinence is worse. Whereas previously I was convinced she just wasn't getting to the litter tray in time this clearly isn't the case.

When I gave breakfast as she stretched and got up from her bed a shower if urine shot out from her and missed poor Will by inches.

When I scooped her up to give her meds earlier it poured out of her.:cry:

On the plus side she's eating well, as usual, and output is normal.


Do you think she is stressed by the treatment at all? That could make things worse before they get better.

I can understand it happening when you scooped her up, as this could perhaps put pressure on her bladder. Perhaps it's sensitive at the moment - did the vet say the extent of the crystals in there? (Am I right in remembering she had crystals? Sorry if not)
 
Do you think she is stressed by the treatment at all? That could make things worse before they get better.

I can understand it happening when you scooped her up, as this could perhaps put pressure on her bladder. Perhaps it's sensitive at the moment - did the vet say the extent of the crystals in there? (Am I right in remembering she had crystals? Sorry if not)

Yes she does have crystals.

Both rabbits take Panacur well - even Will! However poor Nancy is on evil Baytril until next Thursday and I have tried every disguise so I don't have to stress her but to no avail.

Hopefully when she's just down to Panacur it will be less stressful for her.
 
It could be that she is not emptying her bladder fully every time she wees as doing so may sting. Is she on any form of NSAID and has the Vey suggested some fluid therapy ?

If she does not empty her bladder properly this can mean that it becomes more inflamed and she is likely to urinate when handled. She may spot wee and/or leak wee too.

Is her undercarriage clean and dry ?
 
Yes she does have crystals.

Both rabbits take Panacur well - even Will! However poor Nancy is on evil Baytril until next Thursday and I have tried every disguise so I don't have to stress her but to no avail.

Hopefully when she's just down to Panacur it will be less stressful for her.


Ah yes I thought she did. This often means that the bladder isn't emptying fully each time so you may find it empties at odd and sometimes inconvenient times (ie not always when she's in the litter tray.)

Crystals can be quite irritating on the bladder ..... I think a flush from the vet would be the only way to get rid of that. I know Nickybunny has a lot of experience of this sort of thing - might be worth sending her a PM to talk about it?

And Baytril - the work of the devil if you ask me :evil: And the dose is so high! :roll:
 
Ah yes I thought she did. This often means that the bladder isn't emptying fully each time so you may find it empties at odd and sometimes inconvenient times (ie not always when she's in the litter tray.)

Crystals can be quite irritating on the bladder ..... I think a flush from the vet would be the only way to get rid of that. I know Nickybunny has a lot of experience of this sort of thing - might be worth sending her a PM to talk about it?

And Baytril - the work of the devil if you ask me :evil: And the dose is so high! :roll:
Thanks.

We have a vet appointment on Thursday 22nd so will discuss then.

When she was on Baytril earlier in the year we did not have this issue so (glass half empty again) presumed the EC getting worse.

Sent from my SM-G935F using Tapatalk
 
Thanks.

We have a vet appointment on Thursday 22nd so will discuss then.

When she was on Baytril earlier in the year we did not have this issue so (glass half empty again) presumed the EC getting worse.

Sent from my SM-G935F using Tapatalk


Baytril is really good for UTIs, though I found a longer course worked better (you wouldn't want to hear that!)

I don't like invasive stuff like bladder flushes unless it's really necessary. Some vets will use fluids (sub-cut) to help this. Increased water consumption seems to be the very best thing of all - so long as that water is *low calcium* :

https://rabbit.org/health/urolith.html

Increase water consumption. I consider this to be the most important factor in the prevention of the reoccurrence of bladder stones and sludge. If the urine is kept dilute, the possibility of stone or sludge formation is dramatically decreased. Feeding fresh leafy greens that are still wet from washing will help increase water intake (See note on this below). Adding a natural sweetener, not refined sugar, to the drinking water will encourage your pet to drink considerably more. Natural fruit juices with no added sugars, or honey, are an excellent flavoring choice. Test various juice flavors by administering them directly to your rabbit undiluted in a syringe. If your pet takes the juice willingly then try adding it to the drinking water. Record how much water is consumed daily by your pet (this is easy with sipper bottles as they are often marked in ounces on the outside). Use fresh flavored water daily and gradually decrease the amount of flavoring until you see that the rabbit decreases its water consumption. At this point, increase the flavoring just enough to increase water consumption again and continue to use that amount of flavoring daily. Some flavorings that people have reported success with include pineapple, grape, apple and cherry juice and apricot, peach or pear nectar and honey.
 
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It could be that she is not emptying her bladder fully every time she wees as doing so may sting. Is she on any form of NSAID and has the Vey suggested some fluid therapy ?

If she does not empty her bladder properly this can mean that it becomes more inflamed and she is likely to urinate when handled. She may spot wee and/or leak wee too.:

Is her undercarriage clean and dry ?

Thanks Jane.

She was on Metacam however vet stopped it when the EC was confirmed. I did question this as I have read so many times that Metacam and Panacur go hand in hand as EC treatment. However Alex is Exotics Specialist so as he said to stop the Metacam (there had been no improvement in her Symptoms) in case of kidney damage I can't really keep giving it to her.

Sorry for keeping on, I can't think beyond the EC at the moment and keep expecting to find her with a head tilt.:cry:

She is drinking lots, they have an extra bowl and 2 bottles, both rabbits use both options. I am soaking greens/herbs in water before serving and both rabbits do not object!

I am quite encouraged by the helpful comments received today as they intimate that this urinary incontinence (she does leak and spot wee) is due to the bladder crystals rather than the EC.

I have a follow up appointment next Thursday (sooner of course if she deteriorates) and will note down some of the suggestions that you have made.

OH has been here all day and has confirmed no 'accidents'. Naturally when OH scooped her up to give her meds there was no wee! She loves OH more than me. So whilst I was cleaning and disinfecting, the 2 rabbits and OH enjoyed the sun.

Another plus note, when they went back in to their home she went straight to the litter tray for a wee.:D

Again sorry for the ramblings- but my RU friends understand, my real life ones get fed up with me keeping on. And if I hear once more 'all this for a rabbit' murder may be committed.
 
Thanks Jane.

She was on Metacam however vet stopped it when the EC was confirmed. I did question this as I have read so many times that Metacam and Panacur go hand in hand as EC treatment. However Alex is Exotics Specialist so as he said to stop the Metacam (there had been no improvement in her Symptoms) in case of kidney damage I can't really keep giving it to her.

Sorry for keeping on, I can't think beyond the EC at the moment and keep expecting to find her with a head tilt.:cry:

She is drinking lots, they have an extra bowl and 2 bottles, both rabbits use both options. I am soaking greens/herbs in water before serving and both rabbits do not object!

I am quite encouraged by the helpful comments received today as they intimate that this urinary incontinence (she does leak and spot wee) is due to the bladder crystals rather than the EC.

I have a follow up appointment next Thursday (sooner of course if she deteriorates) and will note down some of the suggestions that you have made.

OH has been here all day and has confirmed no 'accidents'. Naturally when OH scooped her up to give her meds there was no wee! She loves OH more than me. So whilst I was cleaning and disinfecting, the 2 rabbits and OH enjoyed the sun.

Another plus note, when they went back in to their home she went straight to the litter tray for a wee.:D

Again sorry for the ramblings- but my RU friends understand, my real life ones get fed up with me keeping on. And if I hear once more 'all this for a rabbit' murder may be committed.


You probably know that Metacam, as a NSAID probably won't show any improvement in symptoms. It's to try and keep down inflammation in the brain and various organs so that the E.C. spores don't erupt and cause further damage. But you can only go by the advice of a savvy and trusted vet :)

I would say it's highly likely that the bladder incontinence is due to the crystals in the urine. It also makes a breeding ground for infection.

How lovely they went to the litter tray - that's encouraging.

And no amount of bunny rambling on here is ever boring! :lol:
 
Thanks Jane.

She was on Metacam however vet stopped it when the EC was confirmed. I did question this as I have read so many times that Metacam and Panacur go hand in hand as EC treatment. However Alex is Exotics Specialist so as he said to stop the Metacam (there had been no improvement in her Symptoms) in case of kidney damage I can't really keep giving it to her.

Sorry for keeping on, I can't think beyond the EC at the moment and keep expecting to find her with a head tilt.:cry:

She is drinking lots, they have an extra bowl and 2 bottles, both rabbits use both options. I am soaking greens/herbs in water before serving and both rabbits do not object!

I am quite encouraged by the helpful comments received today as they intimate that this urinary incontinence (she does leak and spot wee) is due to the bladder crystals rather than the EC.

I have a follow up appointment next Thursday (sooner of course if she deteriorates) and will note down some of the suggestions that you have made.

OH has been here all day and has confirmed no 'accidents'. Naturally when OH scooped her up to give her meds there was no wee! She loves OH more than me. So whilst I was cleaning and disinfecting, the 2 rabbits and OH enjoyed the sun.

Another plus note, when they went back in to their home she went straight to the litter tray for a wee.:D

Again sorry for the ramblings- but my RU friends understand, my real life ones get fed up with me keeping on. And if I hear once more 'all this for a rabbit' murder may be committed.

Sometimes a Vet will be additionally cautious of prescribing Metacam to a Rabbit displaying EC symptoms relating to the Urinary tract as EC can effect the Kidneys and Metacam can be a challenge to the Kidneys. That said, it is really a decision to be made on a case by case basis.

I cant remember if Nancy has had a blood test to check her renal function ? If not that may be something the Vet will suggest at some stage.

Metacam is a Non Steroidal Anti-inflammatory (NSAID) and with EC spores enter the bloodstream via the tubules in the kidneys. Circulating EC spores can then migrate to various body organs, usually the brain and the lenses of the eyes, sometimes other organs too. As the migrating spores erupt into the other body organs they cause an inflammatory inter-cellular response within the effected organ tissues. It is this inflammatory response to erupting EC spores that causes clinical symptoms to present. Hence reducing the inflammatory response to erupting spores will reduce the amount of longterm cellular damage to the effected organ(s)

Clinical symptoms of EC do not present until at 6 weeks after initial infection. By which time the actual protozoal parasite has long since been excreted. It is the spores left behind that can do the damage. Some Rabbits effected by EC will never show clinical symptoms at all.

There is some detailed information about EC here :

http://wildpro.twycrosszoo.org/S/00dis/Parasitic/Encephalitozoonosis.htm

One encouraging fact to take from the link :

''In acute cases (of EC) that present with urinary incontinence -This may resolve with Fenbendazole treatment''
 
Sometimes a Vet will be additionally cautious of prescribing Metacam to a Rabbit displaying EC symptoms relating to the Urinary tract as EC can effect the Kidneys and Metacam can be a challenge to the Kidneys. That said, it is really a decision to be made on a case by case basis.

I cant remember if Nancy has had a blood test to check her renal function ? If not that may be something the Vet will suggest at some stage.

Metacam is a Non Steroidal Anti-inflammatory (NSAID) and with EC spores enter the bloodstream via the tubules in the kidneys. Circulating EC spores can then migrate to various body organs, usually the brain and the lenses of the eyes, sometimes other organs too. As the migrating spores erupt into the other body organs they cause an inflammatory inter-cellular response within the effected organ tissues. It is this inflammatory response to erupting EC spores that causes clinical symptoms to present. Hence reducing the inflammatory response to erupting spores will reduce the amount of longterm cellular damage to the effected organ(s)

Clinical symptoms of EC do not present until at 6 weeks after initial infection. By which time the actual protozoal parasite has long since been excreted. It is the spores left behind that can do the damage. Some Rabbits effected by EC will never show clinical symptoms at all.

There is some detailed information about EC here :

http://wildpro.twycrosszoo.org/S/00dis/Parasitic/Encephalitozoonosis.htm

One encouraging fact to take from the link :

''In acute cases (of EC) that present with urinary incontinence -This may resolve with Fenbendazole treatment''

Thank you Jane.

Nancy had a blood test back in January which showed a normal kidney function which is why Alex prescribed the Metacam whilst we were waiting on the results of the 2nd urine test. It was after the 3rd test confirmed EC he said to stop.

I forgot to report last night that Nancy is clean and dry underneath.
 
Thank you Jane.

Nancy had a blood test back in January which showed a normal kidney function which is why Alex prescribed the Metacam whilst we were waiting on the results of the 2nd urine test. It was after the 3rd test confirmed EC he said to stop.

I forgot to report last night that Nancy is clean and dry underneath.

Good news on both counts xx
 
Thank you Jane.

Nancy had a blood test back in January which showed a normal kidney function which is why Alex prescribed the Metacam whilst we were waiting on the results of the 2nd urine test. It was after the 3rd test confirmed EC he said to stop.

I forgot to report last night that Nancy is clean and dry underneath.


That is really good news that the kidney function was normal, as in advanced E.C. that kidneys are often affected.

I'm also glad you have such a good vet looking after Nancy. :D
 
Nancy, although well in herself, has shown no improvement 11 days in to her course of Panacur.

She has had a follow up vet visit and her weight has dropped slightly from 2.2kg to 2.15kg (vet not worried about this as she was fidgety on the scales).

She has had a scan of her urinary tract and vet does not think the crystals are the cause of the urinary incontinence.

He explained it was difficult with Rabbits to do neurological tests, however he did something with her back legs, which I can only compare to when Supervet Noel turns a cats or dogs paws to check if they spring back. He said her left leg had a slightly slower reaction than normal, which may explain why I have noticed her dragging that leg on one occasion. He has also confirmed she has no arthritis in her rear legs.

We have resumed Metacam alongside the Panacur and she has a follow up appointment in just over 2 weeks when she has finished the Panacur course.

OH usually leaves all the talking and questions to me but when Alex started talking about quality of life and long term prognosis (if she does not significantly improve after 28 days of Panacur)I was unable to speak. But OH said we had no issues with mopping up wee and sweeping up poop, whilst she was her usual hungry, bolshy self.
 
Nancy, although well in herself, has shown no improvement 11 days in to her course of Panacur.

She has had a follow up vet visit and her weight has dropped slightly from 2.2kg to 2.15kg (vet not worried about this as she was fidgety on the scales).

She has had a scan of her urinary tract and vet does not think the crystals are the cause of the urinary incontinence.

He explained it was difficult with Rabbits to do neurological tests, however he did something with her back legs, which I can only compare to when Supervet Noel turns a cats or dogs paws to check if they spring back. He said her left leg had a slightly slower reaction than normal, which may explain why I have noticed her dragging that leg on one occasion. He has also confirmed she has no arthritis in her rear legs.

We have resumed Metacam alongside the Panacur and she has a follow up appointment in just over 2 weeks when she has finished the Panacur course.

OH usually leaves all the talking and questions to me but when Alex started talking about quality of life and long term prognosis (if she does not significantly improve after 28 days of Panacur)I was unable to speak. But OH said we had no issues with mopping up wee and sweeping up poop, whilst she was her usual hungry, bolshy self.

I am sorry that there has been no real improvement so far. Even if Nancy does end up having a longterm problem that will require a lot of management it does not sound as though any of you are ready to give up yet.

In case you may need this for future reference :

http://www.disabledrabbits.com/

https://rabbit.org/journal/1/critically-ill.html
 
I don’t have any advice, but wanted to send lots of vibes for Nancy, and hugs to you xx
 
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