Hello,
Every rabbit is different, some don't mind being picked up but most do mind. Becasue they are prey animals, the only time they'd get picked up in the wild is when they were about to be eaten. Your buns instincts are probably kicking in. How is she in general? You could try spending time with her on the floor at her level so she knows you aren;t a threat and letting her walk on you. Mine have got a lot better since doing this but still don;t like being picked up.