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vhd & mycsi

Hiya

I took Bea when she was three months old. You normally have to wait ten days in-between the two jabs. Marly goes for his VHD tonight, he had his myx on the 20th of December.
 
I believe rabbits must be over 6 weeks of age before they can get their first myxomatosis vaccination. I don't remember if the VHD jab can be given though, I think they need to be a bit older. Your vet would advise.

Routinely myxo injection is given first then the VHD/Cylap injection 14 days later.

Edit: according to RossRabbits, VHD vaccination can be given from 10 to 12 weeks old onwards and annually thereafter.
 
You may find this interesting:

Vet Immunol Immunopathol. 2005 Feb 10;103(3-4):217-21.

Leukocyte-hepatocyte interaction in calicivirus infection: differences between rabbits that are resistant or susceptible to rabbit haemorrhagic disease (RHD).

Ferreira PG, Costa-E-Silva A, Oliveira MJ, Monteiro E, Aguas AP.


Calicivirus infection is lethal for adult rabbits, whereas young rabbits (less than 8-weeks-old) are resistant to the same infectious agent. The virus replicates in the liver and causes a fulminant hepatitis in adult rabbits leading to rabbit haemorrhagic disease (RHD); this is in contrast with the mild and transient hepatitis observed in infected young rabbits. We have used electron microscopy to compare liver leukocyte infiltrates between young (resistant) and adult (susceptible) rabbits, 36-48h after inoculation of the animals with caliciviruses. In adult rabbits, liver infiltrates were made up mostly of heterophils, and they were located near hepatocytes showing severe cellular damage. In contrast, liver leukocyte infiltrates of RHD-resistant young rabbits were dominated by lymphocytes that depicted membrane contacts with the cell surface of undamaged hepatocytes. We conclude that: (i) the cellular inflammatory response of the liver to calicivirus infection is different in rabbits that are susceptible (adult) or resistant (young) to RHD; (ii) leukocyte infiltration of the adult liver by heterophils is probably directed at the removal of dead hepatocytes, whereas the liver lymphocytic infiltration of young rabbits suggests the expression of viral antigens on the surface of liver cells of the RHD-resistant animals.
Click to expand...

I didn't realise that very young rabbits are naturally immune to VHD (called RHD in America) so those that are too young to be vaccinated are relatively protected until vaccination is deemed safe. Don' t think this applies to Myxi though.

Caz

P.S. Admin can edit if they feel experimental detail might offend
 
This may also be of interest:

Vaccine. 2001 Aug 14;19(31):4536-43.


First field trial of a transmissible recombinant vaccine against myxomatosis and rabbit hemorrhagic disease.

Torres JM, Sanchez C, Ramirez MA, Morales M, Barcena J, Ferrer J, Espuna E, Pages-Mante A, Sanchez-Vizcaino JM.


As a novel approach for immunisation of wild rabbits, we have recently developed a transmissible vaccine against myxomatosis and rabbit hemorrhagic disease (RHD) based on a recombinant myxoma virus (MV) expressing the RHDV capsid protein [J. Virol. 74 (2000) 1114]. The efficacy and safety of the vaccine have been extensively evaluated under laboratory conditions. In this study, we report the first limited field trial of the candidate vaccine that was undertaken in an island of 34 Has containing a population of around 300 rabbits. Following administration by the subcutaneous route to 76 rabbits, the vaccine induced specific antibody responses against both myxomatosis and RHDV in all the inoculated rabbits. Furthermore, the recombinant virus exhibited a limited horizontal transmission capacity, promoting seroconversion of around 50% of the uninoculated rabbit population. No evidence of undesirable effects due to the recombinant virus field release was detected.
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