Sonya, welcome to the Forum :wave:
I am sorry to hear about Luna. What a shame she has this, and she's so young too.
I'm glad your vet has done all the appropriate tests and ruled out infection. Also, I guess the blood tests have showed her kidneys functioning normally?
The other suggestion I can make is concerning E.C. (encephalitozoon cuniculi). I don't know whether you've heard of this? It's a parasite that can be caught and transferred from rabbit to rabbit via spores in urine. Lots of rabbits are carriers and have no symptoms throughout their lives. Sometimes when immune systems are low (due to stress or illness) the EC becomes prolific and can cause the symptoms Luna is experiencing. Sometimes we never know what has caused it to flare up.
Whatever the reason, it may be worth you discussing with your vet a 28 day course of Panacur (fenbendazole) for her and her partner. You will need to treat them both at the same time.
More info here:
http://www.houserabbit.co.uk/resources/content/info-sheets/ecuniculi.htm
https://www.vets-now.com/pet-owners/rabbit-care-advice/e-cuniculi-in-rabbits/
http://www.rabbit.org/journal/3-2/e-cuniculi.html
Luna doesn't have all the symptoms, just the urinary one but it may still be worth considering treating as I suggested. Alongside Panacur anti inflammatories are usually given to prevent any further damage by the parasite. So it would be a good idea to keep her on the Metacam (if that's what you are giving her).
Common wisdom also suggests that bleaching litter trays/steaming or cleaning the environment on days 21 and 28 of treatment will interrupt the lifecycle of the parasite. I don't know how valid this is, but certainly cleaning litter trays with a 10% bleach solution and thoroughly rinsing will be a good idea.
Keeping her clean - I usually do a butt bath in 1 inch of water and dry thoroughly and gently with a hair dryer. You can also apply some gentle cream to the area - discuss this with your vet. I know one member here had success with Natalia baby bottom butter - she recommended it worked very well for her rabbit
Let me know what you think and how things go with Luna.[/QUOTE
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Thank you very much for all your helpful suggestions. I had not thought of Vet Bed so will get hold of some. We are back to the Vets again tomorrow and I will ask him about the possibility of it being E C.
She is looking very sorry for herself and has lost more weight so I need to find an answer soon. I will let you know how we get on. Thank you for your time and help. SonyaM and Luna