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Paracetamol ??

J

Jack's-Jane

Wise Old Thumper
I have bought a trial Vetstream membership. On looking at information about pharmacology and therapeutics I came across details for Paracetamol.

Paracetamol
Anna Meredith


Name
Paracetamol.

Class of drug
Non-steroidal anti-inflammatory drug (NSAID).
Uses

Action
Paracetamol is an NSAID but not a cyclo-oxygenase inhibitor.
Modulates the concentration of prostaglandin intermediates.
Antipyretic.
Poor anti-inflammatory effects.
Indications

Antipyretic.
Controls mild to moderate somatic pain.
Can be administered to patients with gastric ulceration as it produces few gastrointestinal (GI) side-effects.
Administration

Routes of administration
Oral: 500 mg tablets; 125 mg/5 ml, 250 mg/5 ml oral suspension.

Dosage
Basic dose
200-500 mg/kg PO.
1-2 mg/ml of drinking water (use flavored products).
Precautions

Use with care
The main concern with paracetamol is hepatotoxicity.
Interactions
with other drugs

Metoclopramide
Enhances paracetamol absorption thereby enhancing its effects.
Adverse reactions

Other reported reactions

Signs of toxicity include anemia, methemaglobinemia and liver failure.


Anyone else rather :shock: :? about this ?


ETA: claims to be based on the Small Animal Formulary. Tennant Bryn (1999)
 
I'm not very knowledgable about medication but not a lot of that looks right to me. The fact that its down as an NSAID and seems to have similar to human doses listed being two key points. Medication isn't my strong point however, I'm learning most of it from your posts :thumb:
 
Jack's-Jane said:
Why what ??
Click to expand...

Why are you :? :shock: ? the dosage is high but that's the only weird thing I've picked up on so I'm not sure why we're meant to be :?:shock: I think I'm missing something..

EDIT: seen your post... was the info specifically for rabbits then? No idea whether it is an NSAID or not, but if it says so in a medical journal I guess it must be, it does say it's not a good one.
 
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If we're talking about acetaminophen (Tylenol) it's my understanding that it's toxic to any animal. Ingestion of this drug constitutes poisoning similar to antifreeze in our country and is treated similarly.
It is not considered anti-inflammatory.
Was this prescribed this for one of your rabbits, Jane? :shock: If so, I'd get a second opinion.
 
MimzMum said:
If we're talking about acetaminophen (Tylenol) it's my understanding that it's toxic to any animal. Ingestion of this drug constitutes poisoning similar to antifreeze in our country and is treated similarly.
It is not considered anti-inflammatory.
Was this prescribed this for one of your rabbits, Jane? :shock: If so, I'd get a second opinion.
Click to expand...

No !!
 
Thanks. I was thinking it's not an NSAID, it's not an opiate, and I couldn't think of anything else.
 
I think Paracetemol is classed by itself usually as it's the only one of its kind in regular use? But just looking around, there are some other medicalish sites that call it an NSAID, although it isn't one.

Perhaps it's lazy reporting or even research? :?
 
I saw a programme the other day where a cat was killed by paracetamol. The vet on there said it was extremely dangerous to all pets as causes organ failure. I presume that included rabbits and small animals not just cats n dogs.
 
Jack's-Jane said:
Because Paracetamol is not a NSAID, it has minimal anti-inflammatory properties.

Also, I was of the impression that it was totally unsuitable for use in Rabbits

The dose seems huge too
Click to expand...

I did work experience in a pharmacy a few weeks ago and read a lot of training guides, paracetamol was definitely not listed as an NSAID
 
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