Cylap was the only VHD vaccine available in the UK between 1997 and early 2007. It is made by Fort Dodge Animal Health and is widely used across Europe and Australia. Cylap can be given as a single dose from 10 weeks of age with a booster every year. In "high risk" situations (for example, a rescue centre in the middle of a VHD outbreak) rabbits can be vaccinated at a younger age, but a second dose will then be required four weeks later.
Lapinject, produced by CEVA Animal Health, became available in the UK in early 2007. It can be given as a single dose from 5 weeks of age with a booster dose every year. Onset of immunity (i.e. the time taken for the vaccine to protect the rabbit from attack by the VHD virus) is 6 days after vaccination.