Several remedies have been proposed to assist in the break up or passage of a hairball. Pineapple juice contains the digestive enzyme bromelain and has been used to treat early cases of trichobezoars; an adult rabbit is given 10 mL of fresh or frozen juice through a stomach tube or intubation needle, SID-BID for 3 days. Both the fluid and the enzyme help to break up the matrix of the hairball. Canned pineapple juice is not as effective because the canning process destroys the enzyme. Papaya contains the enzyme papain, also called papayazyme. Papain enzymes do not break down the hair itself, but may help break down the mucus that holds the hairball together. Human health food or nutrition stores carry bromelain and papayazyme supplements as aids to digestion.